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CYP4F3 blocking peptide

CYP4F3 Antibody (N-term) Blocking Peptide

Gene Names
CYP4F3; CPF3; CYP4F; LTB4H
Synonyms
CYP4F3; CYP4F3 Antibody (N-term) Blocking Peptide; Docosahexaenoic acid omega-hydroxylase CYP4F3; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; 11413-; CYPIVF3; Cytochrome P450 4F3; Cytochrome P450-LTB-omega; Leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-hydroxylase 2; LTB4H; CYP4F3 blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CYP4F3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
520
Cellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane; Single-pass membrane protein
Tissue Location
Isoform CYP4F3A is expressed in the polymorphonuclear leukocytes as well as leukocytes and bone marrow. Isoform CYP4F3B is selectively expressed in liver and kidney and is also the predominant CYP4F isoform in trachea and tissues of the gastrointestinal tract
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for CYP4F3 blocking peptide
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
59,739 Da
NCBI Official Full Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily F member 3
NCBI Official Symbol
CYP4F3
NCBI Official Synonym Symbols
CPF3; CYP4F; LTB4H
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Gene Name
CYP4F3
UniProt Synonym Gene Names
LTB4H; 20-HETE synthase
UniProt Entry Name
CP4F3_HUMAN

NCBI Description

This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

CYP4F3: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.13.30; Membrane protein, integral; Oxidoreductase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: leukotriene-B4 20-monooxygenase activity; monooxygenase activity; oxygen binding

Biological Process: icosanoid metabolic process; leukotriene metabolic process

Research Articles on CYP4F3

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Product Notes

The CYP4F3 cyp4f3 (Catalog #AAA9227762) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CYP4F3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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