CREB3L3 blocking peptide

CREB3L3 Blocking Peptide (Center)

Gene Names

CREB3L3; CREBH; CREB-H; HYST1481

Synonyms

CREB3L3; CREB3L3 Blocking Peptide (Center); Cyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H; Processed cyclic AMP-responsive element-binding protein 3-like protein 3; CREBH; CREB3L3 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 264-274 of HUMAN CREB3L3

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

461

Cellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein

Tissue Location

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CREB3L3 blocking peptide

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.

NCBI and Uniprot Product Information

NCBI GI #

148886847

NCBI GeneID

84699

UniProt Accession #

Q68CJ9; Q6ZMC5; Q96TB9; B2R7S6; B7ZL69; M0QYW7

Molecular Weight

35,845 Da

NCBI Official Full Name

Cyclic AMP-responsive element-binding protein 3-like protein 3

NCBI Official Synonym Full Names

cAMP responsive element binding protein 3 like 3

NCBI Official Symbol

CREB3L3

NCBI Official Synonym Symbols

CREBH; CREB-H; HYST1481

NCBI Protein Information

cyclic AMP-responsive element-binding protein 3-like protein 3

UniProt Protein Name

Cyclic AMP-responsive element-binding protein 3-like protein 3

Protein Family

Cyclic AMP-responsive element-binding protein 3-like protein

UniProt Gene Name

CREB3L3

UniProt Synonym Gene Names

CREBH; cAMP-responsive element-binding protein 3-like protein 3

UniProt Entry Name

CR3L3_HUMAN

NCBI Description

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Description

CREB3L3: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: endoplasmic reticulum; membrane; nucleus

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter

Research Articles on CREB3L3

1. Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance.

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Product Notes

The CREB3L3 creb3l3 (Catalog #AAA9230360) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CREB3L3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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CREB3L3 blocking peptide