CPN1 blocking peptide

CPN1 Antibody (N-term) Blocking Peptide

• Gene Names: CPN1; CPN; SCPN
• Synonyms: CPN1; CPN1 Antibody (N-term) Blocking Peptide; Carboxypeptidase N catalytic chain; CPN; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN; ACBP; CPN1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CPN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 458

• Cellular Location: Secreted, extracellular space.
• Tissue Location: Synthesized in the liver and secreted in plasma
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CPN1 blocking peptide

Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.

NCBI and Uniprot Product Information

• NCBI GI #: 115896
• NCBI GeneID: 1369
• UniProt Accession #: P15169; B1AP59
• Molecular Weight: 52,286 Da
• NCBI Official Full Name: Carboxypeptidase N catalytic chain
• NCBI Official Synonym Full Names: carboxypeptidase N subunit 1
• NCBI Official Symbol: CPN1
• NCBI Official Synonym Symbols: CPN; SCPN
• NCBI Protein Information: carboxypeptidase N catalytic chain
• UniProt Protein Name: Carboxypeptidase N catalytic chain
• Protein Family: Carboxypeptidase
• UniProt Gene Name: CPN1
• UniProt Synonym Gene Names: ACBP; CPN; SCPN
• UniProt Entry Name: CBPN_HUMAN

NCBI Description

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

Uniprot Description

CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.

Protein type: Secreted; EC 3.4.17.3; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24.2

Molecular Function: serine carboxypeptidase activity

Biological Process: peptide metabolic process; protein processing

Disease: Carboxypeptidase N Deficiency