CNR2 blocking peptide

CNR2 Blocking Peptide (N-term)

• Gene Names: CNR2; CB2; CX5; CB-2
• Synonyms: CNR2; CNR2 Blocking Peptide (N-term); Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5; CB2A; CB2B; CNR2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 18-33 of HUMAN CNR2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 360

• Cellular Location: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note: Localizes to apical dendrite of pyramidal neurons
• Tissue Location: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CNR2 blocking peptide

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

NCBI and Uniprot Product Information

• NCBI GI #: 461697
• NCBI GeneID: 1269
• UniProt Accession #: P34972; Q4VBK8; Q5JRH7; Q6B0G7; Q6NSY0; C6ES44
• Molecular Weight: 39,681 Da
• NCBI Official Full Name: Cannabinoid receptor 2
• NCBI Official Synonym Full Names: cannabinoid receptor 2
• NCBI Official Symbol: CNR2
• NCBI Official Synonym Symbols: CB2; CX5; CB-2
• NCBI Protein Information: cannabinoid receptor 2
• UniProt Protein Name: Cannabinoid receptor 2
• Protein Family: Cannabinoid receptor
• UniProt Gene Name: CNR2
• UniProt Synonym Gene Names: CB2A; CB2B; CB-2; CB2; hCB2
• UniProt Entry Name: CNR2_HUMAN

NCBI Description

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; immune response