CIRBP blocking peptide
CIRBP Antibody (C-term) Blocking Peptide
Gene Names
CIRBP; CIRP
Synonyms
CIRBP; CIRBP Antibody (C-term) Blocking Peptide; Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP; A18HNRNP; CIRP; CIRBP blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CIRBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
172
Cellular Location
Nucleus, nucleoplasm. Cytoplasm. Note: Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Tissue Location
Ubiquitous.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for CIRBP blocking peptide
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
26,130 Da
NCBI Official Full Name
Cold-inducible RNA-binding protein
NCBI Official Synonym Full Names
cold inducible RNA binding protein
NCBI Official Symbol
CIRBP
NCBI Official Synonym Symbols
CIRP
NCBI Protein Information
cold-inducible RNA-binding protein
UniProt Protein Name
Cold-inducible RNA-binding protein
Protein Family
UniProt Gene Name
CIRBP
UniProt Synonym Gene Names
A18HNRNP; CIRP
UniProt Entry Name
CIRBP_HUMAN
Uniprot Description
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (). Promotes assembly of stress granules (SGs), when overexpressed.
Research Articles on CIRBP
Similar Products
Product Notes
The CIRBP cirbp (Catalog #AAA9228037) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CIRBP, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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