CDK5RAP1 blocking peptide

CDK5RAP1 Antibody (C-term) Blocking Peptide

• Gene Names: CDK5RAP1; C42; CGI-05; HSPC167; C20orf34
• Synonyms: CDK5RAP1; CDK5RAP1 Antibody (C-term) Blocking Peptide; CDK5 regulatory subunit-associated protein 1; CDK5 activator-binding protein C42; C20orf34; CDK5RAP1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CDK5RAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 601

• Tissue Location: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDK5RAP1 blocking peptide

Specifically inhibits CDK5 activation by CDK5R1.

NCBI and Uniprot Product Information

• NCBI GI #: 32129446
• NCBI GeneID: 51654
• UniProt Accession #: Q96SZ6; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0; A8K7R0
• Molecular Weight: 64,709 Da
• NCBI Official Full Name: CDK5 regulatory subunit-associated protein 1
• NCBI Official Synonym Full Names: CDK5 regulatory subunit associated protein 1
• NCBI Official Symbol: CDK5RAP1
• NCBI Official Synonym Symbols: C42; CGI-05; HSPC167; C20orf34
• NCBI Protein Information: CDK5 regulatory subunit-associated protein 1
• UniProt Protein Name: CDK5 regulatory subunit-associated protein 1
• Protein Family: CDK5RAP1-like protein
• UniProt Gene Name: CDK5RAP1
• UniProt Synonym Gene Names: C20orf34
• UniProt Entry Name: CK5P1_HUMAN

NCBI Description

This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

Uniprot Description

CDK5RAP1: Specifically inhibits CDK5 activation by CDK5R1. Belongs to the methylthiotransferase family. MiaB subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 20q11.21

Molecular Function: 4 iron, 4 sulfur cluster binding; protein kinase regulator activity

Biological Process: negative regulation of cyclin-dependent protein kinase activity