CDH13 blocking peptide

CDH13 Blocking Peptide (Center)

• Gene Names: CDH13; CDHH; P105
• Synonyms: CDH13; CDH13 Blocking Peptide (Center); Cadherin-13; Heart cadherin; H-cadherin; P105; Truncated cadherin; T-cad; T-cadherin; CDHH; CDH13 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 242-256 of HUMAN CDH13
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 713

• Cellular Location: Cell membrane; Lipid-anchor, GPI-anchor.
• Tissue Location: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDH13 blocking peptide

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

NCBI and Uniprot Product Information

• NCBI GI #: 1705552
• NCBI GeneID: 1012
• UniProt Accession #: P55290; Q6GTW4; Q8TBX3; A8W476; A8W477; B7Z590; C9JRI6; J3KN62
• Molecular Weight: 73,787 Da
• NCBI Official Full Name: Cadherin-13
• NCBI Official Synonym Full Names: cadherin 13
• NCBI Official Symbol: CDH13
• NCBI Official Synonym Symbols: CDHH; P105
• NCBI Protein Information: cadherin-13
• UniProt Protein Name: Cadherin-13
• Protein Family: Cadherin
• UniProt Gene Name: CDH13
• UniProt Synonym Gene Names: CDHH; H-cadherin; T-cad; T-cadherin
• UniProt Entry Name: CAD13_HUMAN

NCBI Description

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Uniprot Description

CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: caveola; cytoplasm; extracellular space; focal adhesion; neuron projection; plasma membrane

Molecular Function: adiponectin binding; cadherin binding; low-density lipoprotein binding

Biological Process: calcium-dependent cell-cell adhesion; endothelial cell migration; homophilic cell adhesion; keratinocyte proliferation; lamellipodium biogenesis; localization within membrane; low density lipoprotein mediated signaling; negative regulation of cell adhesion; negative regulation of cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell proliferation; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; Rac protein signal transduction; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; Rho protein signal transduction; sprouting angiogenesis