CABP4 blocking peptide

CABP4 Antibody (C-term) Blocking Peptide

• Gene Names: CABP4; CRSD; CSNB2B
• Synonyms: CABP4; CABP4 Antibody (C-term) Blocking Peptide; Calcium-binding protein 4; CaBP4; CABP4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 275

• Cellular Location: Cytoplasm. Note: Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.
• Tissue Location: Expressed in retina and in the inner hair cells (IHC) of the cochlea
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CABP4 blocking peptide

Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 20178284
• NCBI GeneID: 57010
• UniProt Accession #: P57796; Q8N4Z2; Q8WWY5
• Molecular Weight: 19,600 Da
• NCBI Official Full Name: Calcium-binding protein 4
• NCBI Official Synonym Full Names: calcium binding protein 4
• NCBI Official Symbol: CABP4
• NCBI Official Synonym Symbols: CRSD; CSNB2B
• NCBI Protein Information: calcium-binding protein 4
• UniProt Protein Name: Calcium-binding protein 4
• Protein Family: Calcium-binding protein
• UniProt Gene Name: CABP4
• UniProt Synonym Gene Names: CaBP4
• UniProt Entry Name: CABP4_HUMAN

NCBI Description

This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

CABP4: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. Defects in CABP4 are the cause of congenital stationary night blindness type 2B (CSNB2B). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytosol; synapse; terminal button

Molecular Function: calcium ion binding

Biological Process: visual perception

Disease: Night Blindness, Congenital Stationary, Type 2b