BCL10 blocking peptide
BCL10 Antibody (N-term) Blocking peptide
NCBI and Uniprot Product Information
NCBI Description
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Description
Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.
Protein type: Tumor suppressor; Transcription, coactivator/corepressor; Apoptosis
Chromosomal Location of Human Ortholog: 1p22
Cellular Component: cytoplasm; cytoplasmic microtubule; cytosol; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex
Molecular Function: enzyme binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell death; innate immune response; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein oligomerization; response to food; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway
Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
Research Articles on BCL10
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Product Notes
The BCL10 bcl10 (Catalog #AAA9217798) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BCL10, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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