ATP1B2 blocking peptide

ATP1B2 Blocking Peptide(C-term)

• Gene Names: ATP1B2; AMOG
• Synonyms: ATP1B2; ATP1B2 Blocking Peptide(C-term); Sodium/potassium-transporting ATPase subunit beta-2; Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2; ATP1B2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 262-276 of HUMAN ATP1B2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 290

• Cellular Location: Cell membrane; Single-pass type II membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ATP1B2 blocking peptide

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.

NCBI and Uniprot Product Information

• NCBI GI #: 49574491
• NCBI GeneID: 482
• NCBI Accession #: NP_001669.3
• NCBI GenBank Nucleotide #: NM_001678.4
• UniProt Accession #: P14415; O60444; A0AV17; A8K278; D3DTQ2
• Molecular Weight: 33,367 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit beta-2 isoform 1
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit beta 2
• NCBI Official Symbol: ATP1B2
• NCBI Official Synonym Symbols: AMOG
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit beta-2
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit beta-2
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: ATP1B2
• UniProt Synonym Gene Names: AMOG
• UniProt Entry Name: AT1B2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex

Molecular Function: ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity

Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport