APOC2 blocking peptide

APOC2 Antibody (Center) Blocking Peptide

• Gene Names: APOC2; APO-CII; APOC-II
• Synonyms: APOC2; APOC2 Antibody (Center) Blocking Peptide; Apolipoprotein C-II; Apo-CII; ApoC-II; Apolipoprotein C2; Proapolipoprotein C-II; ProapoC-II; APC2; APOC2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human APOC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 101

• Cellular Location: Secreted.
• Tissue Location: Liver and intestine.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for APOC2 blocking peptide

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

NCBI and Uniprot Product Information

• NCBI GI #: 114022
• NCBI GeneID: 344
• UniProt Accession #: P02655; Q9BS39; Q9UDE3; Q9UNK3; C0JYY4
• Molecular Weight: 11,284 Da
• NCBI Official Full Name: Apolipoprotein C-II
• NCBI Official Synonym Full Names: apolipoprotein C2
• NCBI Official Symbol: APOC2
• NCBI Official Synonym Symbols: APO-CII; APOC-II
• NCBI Protein Information: apolipoprotein C-II
• UniProt Protein Name: Apolipoprotein C-II
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOC2
• UniProt Synonym Gene Names: APC2; Apo-CII; ApoC-II; ProapoC-II
• UniProt Entry Name: APOC2_HUMAN

NCBI Description

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; early endosome; extracellular region; extracellular space

Molecular Function: lipase inhibitor activity; lipid binding; phospholipase activator activity; phospholipase binding; protein homodimerization activity

Biological Process: cholesterol efflux; cholesterol homeostasis; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; retinoid metabolic process; reverse cholesterol transport

Disease: Apolipoprotein C-ii Deficiency