ANKFY1 blocking peptide

ANKFY1 Antibody (C-term) Blocking Peptide

• Gene Names: ANKFY1; ANKHZN; BTBD23; ZFYVE14
• Synonyms: ANKFY1; ANKFY1 Antibody (C-term) Blocking Peptide; Rabankyrin-5; Rank-5; Ankyrin repeat and FYVE domain-containing protein 1; Ankyrin repeats hooked to a zinc finger motif; ANKHZN; KIAA1255; ANKFY1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1169

• Cellular Location: Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note: Also associated with endosomal membranes. Localizes to macropinosomes
• Tissue Location: High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ANKFY1 blocking peptide

Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extend in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the sucellular localization of the retromer complex in a EHD1- dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.

NCBI and Uniprot Product Information

• NCBI GI #: 33514905
• NCBI GeneID: 51479
• UniProt Accession #: Q9P2R3; Q5RKV4; Q9ULG5; A8KA65
• Molecular Weight: 132,821 Da
• NCBI Official Full Name: Rabankyrin-5
• NCBI Official Synonym Full Names: ankyrin repeat and FYVE domain containing 1
• NCBI Official Symbol: ANKFY1
• NCBI Official Synonym Symbols: ANKHZN; BTBD23; ZFYVE14
• NCBI Protein Information: rabankyrin-5
• UniProt Protein Name: Rabankyrin-5
• Protein Family: Rabankyrin
• UniProt Gene Name: ANKFY1
• UniProt Synonym Gene Names: ANKHZN; KIAA1255; Rank-5
• UniProt Entry Name: ANFY1_HUMAN

NCBI Description

This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

ANKFY1: a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: early endosome; endosome membrane; lysosomal membrane; membrane; retromer complex

Molecular Function: protein binding; Rab GTPase binding

Biological Process: endosomal vesicle fusion; endosome localization; positive regulation of pinocytosis; retrograde transport, endosome to Golgi