AKR7A2 blocking peptide

AKR7A2 Antibody (N-term) Blocking Peptide

• Gene Names: AKR7A2; AFAR; AKR7; AFAR1; AFB1-AR1
• Synonyms: AKR7A2; AKR7A2 Antibody (N-term) Blocking Peptide; Aflatoxin B1 aldehyde reductase member 2; 111n11; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; AFAR; AFAR1; AKR7; AKR7A2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human AKR7A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 359

• Cellular Location: Golgi apparatus. Cytoplasm
• Tissue Location: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts Detected at low levels in lung and pancreas (at protein level) Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AKR7A2 blocking peptide

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

NCBI and Uniprot Product Information

• NCBI GI #: 38372871
• NCBI GeneID: 8574
• UniProt Accession #: O43488; O75749; Q5TG63
• Molecular Weight: 39,589 Da
• NCBI Official Full Name: Aflatoxin B1 aldehyde reductase member 2
• NCBI Official Synonym Full Names: aldo-keto reductase family 7 member A2
• NCBI Official Symbol: AKR7A2
• NCBI Official Synonym Symbols: AFAR; AKR7; AFAR1; AFB1-AR1
• NCBI Protein Information: aflatoxin B1 aldehyde reductase member 2
• UniProt Protein Name: Aflatoxin B1 aldehyde reductase member 2
• Protein Family: Aflatoxin B1 aldehyde reductase
• UniProt Gene Name: AKR7A2
• UniProt Synonym Gene Names: AFAR; AFAR1; AKR7; AFB1-AR 1; SSA reductase
• UniProt Entry Name: ARK72_HUMAN

NCBI Description

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

AKR7A2: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: Oxidoreductase; EC 1.1.1.n11

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; phenanthrene-9,10-epoxide hydrolase activity

Biological Process: aldehyde metabolic process; carbohydrate metabolic process; xenobiotic metabolic process