AKR1B1 blocking peptide

AKR1B1 Antibody (C-term) Blocking Peptide

• Gene Names: AKR1B1; AR; ADR; ALR2; ALDR1
• Synonyms: AKR1B1; AKR1B1 Antibody (C-term) Blocking Peptide; Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1; ALDR1; AKR1B1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human AKR1B1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 316

• Cellular Location: Cytoplasm.
• Tissue Location: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AKR1B1 blocking peptide

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

NCBI and Uniprot Product Information

• NCBI GI #: 113596
• NCBI GeneID: 231
• UniProt Accession #: P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9; B2R8N3
• Molecular Weight: 35,853 Da
• NCBI Official Full Name: Aldose reductase
• NCBI Official Synonym Full Names: aldo-keto reductase family 1 member B
• NCBI Official Symbol: AKR1B1
• NCBI Official Synonym Symbols: AR; ADR; ALR2; ALDR1
• NCBI Protein Information: aldose reductase
• UniProt Protein Name: Aldose reductase
• Protein Family: Aldose reductase
• UniProt Gene Name: AKR1B1
• UniProt Synonym Gene Names: ALDR1; AR
• UniProt Entry Name: ALDR_HUMAN

NCBI Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Uniprot Description

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - fructose and mannose; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Carbohydrate Metabolism - galactose; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; response to stress