ADCY8 blocking peptide

ADCY8 Blocking Peptide

Cat. Num. AAA9622525

• Gene Names: ADCY8; AC8; ADCY3; HBAC1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: ADCY8; ADCY8 Blocking Peptide; ADCY3; Adenylate cyclase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8 brain; ATP pyrophosphate-lyase 8; Brain adenylate cyclase 8; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; HBAC1; ADCY8 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for ADCY8 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ADCY8 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 4557257
• NCBI GeneID: 114
• NCBI Accession #: NP_001106.1
• NCBI GenBank Nucleotide #: NM_001115.2
• UniProt Accession #: P40145
• Molecular Weight: 140,122 Da
• NCBI Official Full Name: adenylate cyclase type 8
• NCBI Official Synonym Full Names: adenylate cyclase 8 (brain)
• NCBI Official Symbol: ADCY8
• NCBI Official Synonym Symbols: AC8; ADCY3; HBAC1
• NCBI Protein Information: adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase
• UniProt Protein Name: Adenylate cyclase type 8
• Protein Family: Adenylate cyclase
• UniProt Gene Name: ADCY8
• UniProt Synonym Gene Names: AC8
• UniProt Entry Name: ADCY8_HUMAN

NCBI Description

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

Uniprot Description

ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Transporter; Nucleotide Metabolism - purine; Lyase; Membrane protein, multi-pass; EC 4.6.1.1; Membrane protein, integral; Transporter, aquaporin family; Adenylyl cyclase

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport