ACOT8 blocking peptide

ACOT8 Blocking Peptide (C-term)

• Gene Names: ACOT8; hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III
• Synonyms: ACOT8; ACOT8 Blocking Peptide (C-term); Acyl-coenzyme A thioesterase 8; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II; hACTE-III; hACTEIII; hTE; ACTEIII; PTE1; PTE2; ACOT8 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 275-290 of HUMAN ACOT8
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 319

• Cellular Location: Peroxisome.
• Tissue Location: Detected in a T-cell line (at protein level). Ubiquitous.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ACOT8 blocking peptide

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 14285685
• NCBI GeneID: 10005
• UniProt Accession #: O14734; O15261; Q17RX4
• Molecular Weight: 35,914 Da
• NCBI Official Full Name: Acyl-coenzyme A thioesterase 8
• NCBI Official Synonym Full Names: acyl-CoA thioesterase 8
• NCBI Official Symbol: ACOT8
• NCBI Official Synonym Symbols: hTE; NAP1; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III
• NCBI Protein Information: acyl-coenzyme A thioesterase 8
• UniProt Protein Name: Acyl-coenzyme A thioesterase 8
• Protein Family: Acyl-coenzyme A thioesterase
• UniProt Gene Name: ACOT8
• UniProt Synonym Gene Names: ACTEIII; PTE1; PTE2; Acyl-CoA thioesterase 8; PTE-1; hACTE-III; hACTEIII; hTE
• UniProt Entry Name: ACOT8_HUMAN

NCBI Description

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

Uniprot Description

ACOT8: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.27; Hydrolase

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: peroxisomal matrix

Molecular Function: acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; CoA hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding; receptor binding

Biological Process: acyl-CoA metabolic process; bile acid biosynthetic process; dicarboxylic acid catabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; negative regulation of CD4 biosynthetic process; peroxisome fission