Structure
U-0126 Biochemical
U-0126
Purity
In solution, U 0126 forms a mixture of isomers, but this does not affect biological activity.>= 98% (TLC)
Synonyms
U-0126; U-0126 biochemical
Purity/Purification
In solution, U 0126 forms a mixture of isomers, but this does not affect biological activity.
>= 98% (TLC)
>= 98% (TLC)
Form/Format
White solid
Formula
C18H16N6S2
CAS Number
109522-58-2
Solubility
Soluble in DMSO (>10mg/ml) or 100% ethanol (2mg/ml).
Preparation and Storage
Long term: Ambient
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20 degree C for up to 3 months.
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20 degree C for up to 3 months.
Structure
Structure
Related Product Information for U-0126 biochemical
Binding of extracellular growth factors to cell surface receptors often results in actiavtion of the mitogen-ativated protein kinase (MAPK). MAPK is regulated by MAPK kinase, also called MEK. Deprivation of growth factors during cell culture or intracellular MEK inhibition leads to inhibition of proliferation and apoptotic cell death. N Blank et al. (2002) have shown that U0126, a common used MEK inhibitor and compound that itself has no intrinsic fluorescence in vitro but develops an intensive fluorsecence during cell culture which can be observed in all fluorescence channels with a predominance in the FL1 channel (525nm). Therefore either the use of PD98,059 or PD184352 as an alternative for U126 or nonfluorometric methods for detection of apoptosis should be considered.
Product Categories/Family for U-0126 biochemical
Similar Products
Product Notes
The U-0126 (Catalog #AAA565434) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "U-0126, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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