Structure
(Structure of T9153.)
Tubastatin A Biochemical
Tubastatin A ((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol- 5(2H)-yl)methyl)benzamide)
Purity
Highly Purified~98% (HPLC)
Synonyms
Tubastatin A; Tubastatin A ((2-methyl-3; 4-dihydro-1H-pyrido[4; 3-b]-indol- 5(2H)-yl)methyl)benzamide); Tubastatin A biochemical
Purity/Purification
Highly Purified
~98% (HPLC)
~98% (HPLC)
Form/Format
Supplied as an off-white solid. Reconstitute with DMSO (~90mg/ml), sterile ddH2O (~4mg/ml), 2% TWEEN-80/ddH2O (~2mg/ml) or 30% PEG (avg. MW = 400 g/mol)/50 mM phosphate buffer (pH = 2.25) (25mg/ml) (heating is required to initially dissolve the compound).
CAS Number
1239262-52-2
Molecular Formula
C??H??N?O?.HCl
Preparation and Storage
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Structure
(Structure of T9153.)
Structure
(Structure of T9153.)
Related Product Information for Tubastatin A biochemical
Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15nM for HDAC6 vs 16.4uM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5uM with near complete protection at 10uM.
Product Categories/Family for Tubastatin A biochemical
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Product Notes
The Tubastatin A (Catalog #AAA6022606) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tubastatin A, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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