Structure
Tasisulam Biochemical
Tasisulam
Purity
>98% (HPLC)
Synonyms
Tasisulam; LY 573636; Tasisulam biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 77mg/mL (185.5mM)
Ethanol: 77mg/mL (185.5mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 77mg/mL (185.5mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
E3 Ubiquitin Ligase
Receptor
Caspase
Chemical Name
N-[(5-bromo-2-thienyl)sulfonyl]-2, 4-dichloro-benzamide
SMILES
O=S(C1=CC=C(Br)S1)(NC(C2=CC=C(Cl)C=C2Cl)=O)=O
Molecular Formula
C11H6BrCl2NO3S2
CAS Number
519055-62-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Tasisulam biochemical
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death; shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines; promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation; causes aberrant pre-mRNA splicing. Blood Cancer Phase 1 Discontinued
Product Categories/Family for Tasisulam biochemical
References
1. Meier T, et al. Mol Cancer Ther. 2011 Nov; 10 (11):2168-78.
2. Haritunians T, et al. Oncol Rep. 2008 Nov; 20 (5):1237-42.
3. Han T, et al. Science. 2017 Apr 28; 356 (6336). pii: eaal3755.
2. Haritunians T, et al. Oncol Rep. 2008 Nov; 20 (5):1237-42.
3. Han T, et al. Science. 2017 Apr 28; 356 (6336). pii: eaal3755.
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Product Notes
The Tasisulam (Catalog #AAA3604815) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tasisulam, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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