Chemical Structure
Spliceostatin A Biochemical
Spliceostatin A
Purity
>98%
Synonyms
Spliceostatin A; Spliceostatin A biochemical
Purity/Purification
>98%
Solubility
DMSO
Formula
C28H43NO8
SMILES
C[C@H]1C[C@H] ([C@H] (O[C@H]1C/C=C (\C)/C=C/[C@@H]2[C@H] ([C@@]3 (C[C@@] (O2) (C)OC)CO3)O)C)NC (=O)/C=C/[C@H] (C)OC (=O)C
CAS Number
391611-36-2
Preparation and Storage
Store at -20 degree C for 3 years (powder form); at -20 degree C for 6 months (Solution base)
Chemical Structure
Chemical Structure
Related Product Information for Spliceostatin A biochemical
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
References
Arfaoui A,.et al. A genome-wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells, EMBO Mol Med, 2019, Oct;11 (10):e9930 PMID: 31476112
KE Mengwasser,.et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets, Mol Cell, 2019, S1097-2765 (18)31062-1 PMID: 30686591
Sahar AlShareef,.et al. Herboxidiene triggers splicing repression and abiotic stress responses in plants, BMC Genomics, 2017, 18: 260 PMID: 28347276Ling Y,.et al. Pre-mRNA splicing repression triggers abiotic stress signaling in plants, Plant J, 2017, Jan;89 (2):291-309 PMID: 27664942Matthew J. Hangauer,.et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition, Nature, 2017, Nov 9; 551 (7679): 247-250. PMID: 29088702Ji Hyun Kim,.et al. Mitotic control by mRNA splicing regulators ensures primary cilia formation, Animal Cells and Systems, 2017, 21:1, 17-22 PMID: 30460047M Tanikawa,.et al. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing, Oncogenesis, 2016, Dec; 5 (12): e280 PMID: 27991914Ji Hyun Kim,.et al. Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation, Biochim Biophys Acta, 2016, Jun; 1863 (6 Pt A): 1307-1318 PMID: 27033521
KE Mengwasser,.et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets, Mol Cell, 2019, S1097-2765 (18)31062-1 PMID: 30686591
Sahar AlShareef,.et al. Herboxidiene triggers splicing repression and abiotic stress responses in plants, BMC Genomics, 2017, 18: 260 PMID: 28347276Ling Y,.et al. Pre-mRNA splicing repression triggers abiotic stress signaling in plants, Plant J, 2017, Jan;89 (2):291-309 PMID: 27664942Matthew J. Hangauer,.et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition, Nature, 2017, Nov 9; 551 (7679): 247-250. PMID: 29088702Ji Hyun Kim,.et al. Mitotic control by mRNA splicing regulators ensures primary cilia formation, Animal Cells and Systems, 2017, 21:1, 17-22 PMID: 30460047M Tanikawa,.et al. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing, Oncogenesis, 2016, Dec; 5 (12): e280 PMID: 27991914Ji Hyun Kim,.et al. Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation, Biochim Biophys Acta, 2016, Jun; 1863 (6 Pt A): 1307-1318 PMID: 27033521
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Product Notes
The Spliceostatin A (Catalog #AAA387385) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Spliceostatin A, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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