Structure
SPDP Crosslinker Biochemical
SPDP Crosslinker
Purity
>=90% by NMR
Synonyms
SPDP Crosslinker; N-succinimidyl-3-(2-pyridyldithio)propionate; 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester; 3-(2-Pyridyldithio)propionic acid NHS ester; SPDP Crosslinker biochemical
Purity/Purification
>=90% by NMR
Form/Format
Appearance: White to Off-white Solid
CAS Number
68181-17-9
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
No
MDL Number
MFCD00009636
PubChem CID
100682
Solubility/Reconstitution Instructions
DMSO or DMF
SMILES
C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
InChi
InChI=1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChi Key
JWDFQMWEFLOOED-UHFFFAOYSA-N
Handling
Protect from moisture
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Shelf Life: 36 months
Structure
Structure
Related Product Information for SPDP Crosslinker biochemical
Background: KEY FEATURES:
SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups)
SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343 nm, the reaction can be easily followed
Contains a disulfide linkage in its spacer arm with a length of 6.8 A?
The spacer is cleavable with reducing agent, such as DTT, TCEP, etc.APPLICATIONS:
Reversible crosslinking of proteins
N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains
Useful for adding sulfhydryl groups to proteins by attachment to lysine residues
Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates
SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups)
SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343 nm, the reaction can be easily followed
Contains a disulfide linkage in its spacer arm with a length of 6.8 A?
The spacer is cleavable with reducing agent, such as DTT, TCEP, etc.APPLICATIONS:
Reversible crosslinking of proteins
N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains
Useful for adding sulfhydryl groups to proteins by attachment to lysine residues
Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates
Product Categories/Family for SPDP Crosslinker biochemical
Similar Products
Product Notes
The SPDP Crosslinker (Catalog #AAA842957) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SPDP Crosslinker, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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