Structure
Smad3 Inhibitor, SIS3 Biochemical
Smad3 Inhibitor, SIS3
Purity
>=98% by HPLC
Synonyms
Smad3 Inhibitor; SIS3; (2E)-1-(6; 7-Dimethoxy-3; 4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2; 3-b]pyridin-3-yl)-propenone hydrochloride; SIS3 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Yellow solid
CAS Number
521984-48-5
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD09265258
PubChem CID
16079005
Molecular Formula
C28H27N3O3
Solubility/Reconstitution Instructions
DMSO (>20 mg/ml)
SMILES
CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
InChi
InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChi Key
CDKIEBFIMCSCBB-CALJPSDSSA-N
Handling
Protect from light and moisture
Preparation and Storage
At -20 degree C. Protect from light and moisture
Structure
Structure
Related Product Information for Smad3 Inhibitor, SIS3 biochemical
Background: A potent and selective inhibitor of Smad3 function. SIS3 selectively inhibits TGF-beta1/ALK5-induced Smad3 phosphorylation. Also inhibits the TGF-beta1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site.
Product Categories/Family for Smad3 Inhibitor, SIS3 biochemical
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Product Notes
The Smad3 Inhibitor, SIS3 (Catalog #AAA842292) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Smad3 Inhibitor, SIS3, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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