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Protein Kinase Inhibitor H-89 Biochemical
Protein Kinase Inhibitor H-89 (PKI, N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) (N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide)
Purity
Molecular Biology Grade
Synonyms
Protein Kinase Inhibitor H-89; Protein Kinase Inhibitor H-89 (PKI; N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) (N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide); Protein Kinase Inhibitor H-89 biochemical
Purity/Purification
Molecular Biology Grade
CAS Number
127243-85-0
Molecular Formula
C20H20N3O2SBr
Preparation and Storage
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Testing Data
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Testing Data
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Related Product Information for Protein Kinase Inhibitor H-89 biochemical
Protein Kinase Inhibitors
KN-04, which closely resembles KN-62 in its chemical structure, exhibits a weak protein kinase inhibition and is useful as a control for KN-62.
KN-62 and KN-04 are useful tools for elucidation of the function of the enzyme in relation to cellular responses.
H-89 and H-88 have a potent and selective inhibitory effect against cyclic AMP-dependent protein kinase (Protein Kinase A).
H-89 is most powerful among various protein kinase A inhibitors.
H-85 closely resembles H-89 in its chemical structure. It is not specific to Protein Kinase A and has similar inhibitory effects on other kinases ; hence this compound can be used as a negative control of H-89.
CKI-7 has a potent inhibitory effect against casein kinase I and a much weaker effect on casein kinase II as well as other protein kinases.
CKI-8, a derivative of CKI-7, is used as an affinity ligand to purify casein kinase I. These newly synthesized compounds should serve as useful tools for elucidating the biological significance of casein kinase I -mediated reactions.
KN-93, a modified type of KN-62, is also a potent and specific inhibitor of Ca++/CaM Kinase II and its solubility in buffered solution is superior to KN-62.
KN-92, which closely resembles KN-93 in its chemical structure, exhibits no inhibitory effect to Ca++/CaM Kinase II and is used as a control for KN- 93.
KN-04, which closely resembles KN-62 in its chemical structure, exhibits a weak protein kinase inhibition and is useful as a control for KN-62.
KN-62 and KN-04 are useful tools for elucidation of the function of the enzyme in relation to cellular responses.
H-89 and H-88 have a potent and selective inhibitory effect against cyclic AMP-dependent protein kinase (Protein Kinase A).
H-89 is most powerful among various protein kinase A inhibitors.
H-85 closely resembles H-89 in its chemical structure. It is not specific to Protein Kinase A and has similar inhibitory effects on other kinases ; hence this compound can be used as a negative control of H-89.
CKI-7 has a potent inhibitory effect against casein kinase I and a much weaker effect on casein kinase II as well as other protein kinases.
CKI-8, a derivative of CKI-7, is used as an affinity ligand to purify casein kinase I. These newly synthesized compounds should serve as useful tools for elucidating the biological significance of casein kinase I -mediated reactions.
KN-93, a modified type of KN-62, is also a potent and specific inhibitor of Ca++/CaM Kinase II and its solubility in buffered solution is superior to KN-62.
KN-92, which closely resembles KN-93 in its chemical structure, exhibits no inhibitory effect to Ca++/CaM Kinase II and is used as a control for KN- 93.
Product Categories/Family for Protein Kinase Inhibitor H-89 biochemical
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Product Notes
The Protein Kinase Inhibitor H-89 (Catalog #AAA6023990) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Protein Kinase Inhibitor H-89, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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