Structure
Procaspase-3 activator 1541B Biochemical
Procaspase-3 activator 1541B
Purity
>98% (HPLC)
Synonyms
Procaspase-3 activator 1541B; Compound 1541B; Procaspase-3 activator 1541B biochemical
Purity/Purification
>98% (HPLC)
Target
Caspase
Receptor
Caspase
Chemical Name
8-hydroxy-N-(3-(imidazo[1, 2-a]pyridin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide
SMILES
O=C(C(C1=O)=CC2=C(O1)C(O)=CC=C2)NC3=CC=CC(C4=CN5C=CC=CC5=N4)=C3
Molecular Formula
C23H15N3O4
CAS Number
1170689-68-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Procaspase-3 activator 1541B biochemical
Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3uM; shows no activition activity for procaspases-6; shows considerable synergy in activating procaspase-3 in vitro combined with PAC-1, stimulates rapid and dramatic maturation of procaspase-3 in multiple cancer cell lines; effectively reduces tumor burden in a murine lymphoma model combined with PAC-1, but not treated alone.
Product Categories/Family for Procaspase-3 activator 1541B biochemical
References
1. Wolan DW, et al. Science. 2009 Nov 6; 326 (5954):853-8.
2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29; 136 (4):1312-9.
3. Julien O, et al. Nat Chem Biol. 2014 Nov; 10 (11):969-76.
2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29; 136 (4):1312-9.
3. Julien O, et al. Nat Chem Biol. 2014 Nov; 10 (11):969-76.
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Product Notes
The Procaspase-3 activator 1541B (Catalog #AAA3600573) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Procaspase-3 activator 1541B, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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