Structure
P62-mediated mitophagy inducer Biochemical
P62-mediated mitophagy inducer
Purity
>98% (HPLC)
Synonyms
P62-mediated mitophagy inducer; PMI; P62-mediated mitophagy inducer biochemical
Purity/Purification
>98% (HPLC)
Target
Mitophagy
Receptor
Mitophagy
Chemical Name
1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1, 2, 3-triazole
SMILES
C1=CC(=CC(=C1)[N+](=O)[O-])C2=CN(N=N2)C3=CC(=CC=C3)I
Molecular Formula
C14H9IN4O2
CAS Number
1809031-84-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for P62-mediated mitophagy inducer biochemical
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
Product Categories/Family for P62-mediated mitophagy inducer biochemical
References
1. East DA, et al. Chem Biol. 2014 Nov 20; 21 (11):1585-96.
2. Bertrand HC, et al. J Med Chem. 2015 Sep 24; 58 (18):7186-94.
3. Holmstrm KM, et al. Curr Opin Toxicol. 2016 Dec; 1:80-91.
2. Bertrand HC, et al. J Med Chem. 2015 Sep 24; 58 (18):7186-94.
3. Holmstrm KM, et al. Curr Opin Toxicol. 2016 Dec; 1:80-91.
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Product Notes
The P62-mediated mitophagy inducer (Catalog #AAA3602772) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "P62-mediated mitophagy inducer, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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