Structure
ONO-2952 Biochemical
ONO-2952
Purity
>98% (HPLC)
Synonyms
ONO-2952; ONO 2952; ONO2952; ONO-2952 biochemical
Purity/Purification
>98% (HPLC)
Target
TSPO
Receptor
TSPO
Chemical Name
1-[(1S)-1-(4-Chloro-2-methoxyphenyl)-5-fluoro- 1, 9-dihydrospiro[b-carboline-4, 10 -cyclopropan]-2(3H)-yl]ethanone
SMILES
CC(N([C@H]1C2=CC=C(Cl)C=C2OC)CC3(C4=C1NC5=C4C(F)=CC=C5)CC3)=O
Molecular Formula
C22H20ClFN2O2
CAS Number
895169-20-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ONO-2952 biochemical
A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3nM for both rat and human TSPO; displays high selectivity over 98 other receptors, transporters, ion channels and enzymes; inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress; suppresses conditioned fear stress-induced freezing behavior in rats with an efficacy equivalent to that of diazepam, but without not affect learning and memory. Irritable Bowel Syndrome Phase 2 Clinical
Product Categories/Family for ONO-2952 biochemical
References
1. Mitsui K, et al. Neuropharmacology. 2015 Dec; 99:51-66.
2. Mitsui K, et al. J Pharmacol Exp Ther. 2017 Mar; 360 (3):457-465.
3. Frankle WG, et al. Synapse. 2017 Jul; 71 (7).
4. Mitsui K, et al. Neuropharmacology. 2015 Dec; 99:51-66.
2. Mitsui K, et al. J Pharmacol Exp Ther. 2017 Mar; 360 (3):457-465.
3. Frankle WG, et al. Synapse. 2017 Jul; 71 (7).
4. Mitsui K, et al. Neuropharmacology. 2015 Dec; 99:51-66.
Similar Products
Product Notes
The ONO-2952 (Catalog #AAA3606442) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ONO-2952, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
