Testing Data
(Linamarin (2-(b-D-Glucopyranosyloxy)-2-methyl-propanenitrile, Phaseolunatin))
Linamarin Biochemical
Linamarin (2-(b-D-Glucopyranosyloxy)-2-methyl-propanenitrile, Phaseolunatin)
Synonyms
Linamarin; Linamarin (2-(b-D-Glucopyranosyloxy)-2-methyl-propanenitrile; Phaseolunatin); Linamarin biochemical
Molecular Formula
C10H17NO6
Melting Point
142-143 degree C
Solubility
Hot Acetone, Alcohol, Water
Preparation and Storage
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Testing Data
(Linamarin (2-(b-D-Glucopyranosyloxy)-2-methyl-propanenitrile, Phaseolunatin))
Testing Data
(Linamarin (2-(b-D-Glucopyranosyloxy)-2-methyl-propanenitrile, Phaseolunatin))
Related Product Information for Linamarin biochemical
Linamarin can be found in the seed, skins and embryos of flax. Epidemic spastic paraparesis (konzo) found in tropical and subtropical countries is known to be caused by long-term intake of cassava (Manihot esculenta Crantz), which contains a cyanoglucoside linamarin (-hydroxyisobutyronitrile- -D-glucopyranoside). It has been reported that linamarin is enzymatically converted to cyanide by bacteria in the intestine, and this is absorbed into the blood and then damages neural cells. However, unmetabolized linamarin was found in the urine after oral administration of cassava; thus, we hypothesized that konzo could be caused by direct toxicity of the unmetabolized linamarin that was transferred to the brain and could be transported into neural cells via a glucose transporter. In the present study it was confirmed that linamarin directly damaged neural culture pheochromocytoma cell (PC) 12 cells; 0·10mM-linamarin caused cell death at 13·31 (SD 2·07)%, which was significantly different from that of control group (3·18 (SD 0·92) %, P=0·0004). Additional 10uM-cytochalasin B, an inhibitor of a glucose transporter, prevented cell death: the percentage of dead cells significantly decreased to 6·06 (SD 1·98), P=0·0088). Furthermore, glucose also prevented cell death. These present results strongly suggest that linamarin competes with cytochalasin B and glucose for binding to a glucose transporter and enters into cells via glucose transporter.
Product Categories/Family for Linamarin biochemical
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Product Notes
The Linamarin (Catalog #AAA6079504) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Linamarin, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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