Structure
KN-62 Biochemical
KN-62
Purity
>98% (HPLC)
Synonyms
KN-62; KN 62; KN62; KN-62 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CaMK
Receptor
CaMKV; CaMKII
Chemical Name
5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester
SMILES
CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
Molecular Formula
C38H35N5O6S2
CAS Number
127191-97-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for KN-62 biochemical
KN-62 is a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK II) with Ki of 900nM for rat brain CaMK II; potently antagonizes ATP-stimulated Ba2+ influx into fura-2 loaded human lymphocytes with IC50 of 12.7nM, inhibits ATP-stimulated ethidium+ uptake with IC50 of 13.1nM; causes hypertension and tachycardia in rats, associated with the diminished rate of GABA release in cerebrospinal fluid.
Product Categories/Family for KN-62 biochemical
References
1. Tokumitsu H, et al. J Biol Chem. 1990 Mar 15; 265 (8):4315-20.
2. Ishikawa N, et al. J Pharmacol Exp Ther. 1990 Aug; 254 (2):598-602.
3. Ito I, et al. Neurosci Lett. 1991 Jan 2; 121 (1-2):119-21.
4. Gargett CE, et al. Br J Pharmacol. 1997 Apr; 120 (8):1483-90.
2. Ishikawa N, et al. J Pharmacol Exp Ther. 1990 Aug; 254 (2):598-602.
3. Ito I, et al. Neurosci Lett. 1991 Jan 2; 121 (1-2):119-21.
4. Gargett CE, et al. Br J Pharmacol. 1997 Apr; 120 (8):1483-90.
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Product Notes
The KN-62 (Catalog #AAA3601138) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KN-62, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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