InS3-54A18 Biochemical
InS3-54A18
Purity
>98% (HPLC)
Synonyms
InS3-54A18; inS3-54-A18; inS3-54A18; inS3-54 A18; inS354-A18; InS3-54A18 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=150mg/mL (401.25mM)
Target
STAT
Receptor
STAT
Chemical Name
3-(4-chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1, 3-dihydro-2H-pyrrol-2-one
SMILES
O=C1N(C2=CC=C(O)C=C2)C(C3=CC=CC=C3)=C/C1=C/C4=CC=C(Cl)C=C4
Molecular Formula
C23H16ClNO2
CAS Number
328998-53-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for InS3-54A18 biochemical
InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties; not only binds directly to the DBD and inhibits the DNA-binding activity of STAT3 both in vitro and in situ but also effectively inhibits the constitutive and IL-6-stimulated expression of STAT3 downstream target genes; InS3-54A18 is completely soluble in an oral formulation and effectively inhibits lung xenograft tumor growth and metastasis with little adverse effect on animals.
Product Categories/Family for InS3-54A18 biochemical
References
1. Huang W, et al. Oncogene. 2016 Feb 11; 35 (6):783-92.
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Product Notes
The InS3-54A18 (Catalog #AAA3604080) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "InS3-54A18, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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