Structure
Herbimycin A Biochemical | hbmRI biochemical
Herbimycin A
Purity
>=98% by HPLC
Synonyms
Herbimycin A; (15R)-17-demethoxy-15-methoxy-11-O-methyl-geldanamycin; hbmRI biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Appearance: Yellow lyophilized solid
Sequence Length
947
CAS Number
70563-58-5
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD00151702
PubChem CID
6436247
Solubility/Reconstitution Instructions
DMSO (~ 6 mg/ml)
SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
InChi
InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
InChi Key
MCAHMSDENAOJFZ-GDYSMBPZSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Shelf Life: 36 months
Structure
Structure
Related Product Information for hbmRI biochemical
Background: Herbimycin A is an ansamycin antibiotic isolated from Streptomyces sp. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity. It also inhibits angiogenesis in a rat retinopathy model.
Product Categories/Family for hbmRI biochemical
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
574.7
NCBI Official Full Name
HbmRI
UniProt Protein Name
HbmRI
UniProt Gene Name
hbmRI
UniProt Entry Name
Q49BC8_STRHY
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Product Notes
The Herbimycin A hbmri (Catalog #AAA842383) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Herbimycin A, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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