Structure
GSK4112 Biochemical
GSK4112
Purity
>98% (HPLC)
Synonyms
GSK4112; SR6452; GSK-4112; GSK 4112; SR-6452; SR 6452; GSK4112 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Autophagy
Receptor
Rev-ErbBalpha
Chemical Name
Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1, 1-dimethylethyl ester
SMILES
O=C(OC(C)(C)C)CN(CC1=CC=C(Cl)C=C1)CC2=CC=C([N+]([O-])=O)S2
Molecular Formula
C18H21ClN2O4S
CAS Number
1216744-19-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK4112 biochemical
A potent and selective small molecule Rev-erbalpha agonist with EC50 of 0.4uM in biochemical assay; mediates the repression of Rev-erbalpha target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.
Product Categories/Family for GSK4112 biochemical
References
1. Grant D, et al. ACS Chem Biol. 2010 Oct 15; 5 (10):925-32.
2. Trump RP, et al. J Med Chem. 2013 Jun 13; 56 (11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2; 11 (11):1987-1997.
2. Trump RP, et al. J Med Chem. 2013 Jun 13; 56 (11):4729-37.
3. Chandra V, et al. Autophagy. 2015 Nov 2; 11 (11):1987-1997.
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Product Notes
The GSK4112 (Catalog #AAA3600812) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK4112, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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