Structure
Doravirine Biochemical
Doravirine
Purity
>98% (HPLC)
Synonyms
Doravirine; MK-1439; MK1439; Doravirine biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
HIV
Receptor
HIV-1
Chemical Name
Benzonitrile, 3-chloro-5-[[1-[(4, 5-dihydro-4-methyl-5-oxo-1H-1, 2, 4-triazol-3-yl)methyl]-1, 2-dihydro-2-oxo-4-(trifluoromethyl)-3-pyridinyl]oxy]
SMILES
N#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3C)=NNC3=O)C2=O)=CC(Cl)=C1
Molecular Formula
C17H11ClF3N5O3
CAS Number
1338225-97-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Doravirine biochemical
Doravirine (MK-1439, MK1439) is a novel, highly specific HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 12, 9.7, and 9.7nM against WT, K103N, and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay; shows excellent potency in suppressing the replication of WT virus with EC95 of 20nM, as well as K103N, Y181C, and K103N/Y181C mutant viruses with EC95 of 43, 27, and 55nM, respectively. HIV Infection Phase 3 Clinical
Product Categories/Family for Doravirine biochemical
References
1. Lai MT, et al. Antimicrob Agents Chemother. 2014; 58 (3):1652-63.
2. Ctie B, et al. Bioorg Med Chem Lett. 2014 Feb 1; 24 (3):917-22.
3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan; 59 (1):590-8.
2. Ctie B, et al. Bioorg Med Chem Lett. 2014 Feb 1; 24 (3):917-22.
3. Feng M, et al. Antimicrob Agents Chemother. 2015 Jan; 59 (1):590-8.
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Product Notes
The Doravirine (Catalog #AAA3601354) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Doravirine, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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