Structure
D-alpha-Hydroxyglutaric acid disodium salt Biochemical
D-alpha-Hydroxyglutaric acid disodium salt
Purity
>98% (HPLC)
Synonyms
D-alpha-Hydroxyglutaric acid disodium salt; D-2-HG; D-2-hydroxyglutarate; D-alpha-Hydroxyglutaric acid disodium salt biochemical
Purity/Purification
>98% (HPLC)
Suitability
H2O: >=32mg/mL
Target
Histone Demethylase
Receptor
alpha-KG
Chemical Name
Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)
SMILES
[O-]C(CC[C@H](C([O-])=O)O)=O.[Na+].[Na+]
Molecular Formula
C5H6Na2O5
CAS Number
103404-90-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for D-alpha-Hydroxyglutaric acid disodium salt biochemical
A competitive inhibitor of multiple alpha-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with alpha-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells
Product Categories/Family for D-alpha-Hydroxyglutaric acid disodium salt biochemical
References
1. Xu W, et al. Cancer Cell. 2011 Jan 18; 19 (1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1; 22 (3):508-15.
2. Fu X, et al. Cell Metab. 2015 Sep 1; 22 (3):508-15.
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Product Notes
The D-alpha-Hydroxyglutaric acid disodium salt (Catalog #AAA3600168) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "D-alpha-Hydroxyglutaric acid disodium salt, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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