Structure
AZD9496 Biochemical
AZD9496
Purity
>98% (HPLC)
Synonyms
AZD9496; AZD-9496; AZD9496 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=104.5mg/mL
Target
Estrogen Receptor/ERR
Receptor
ERalpha
Chemical Name
2-Propenoic acid, 3-[3, 5-difluoro-4-[(1R, 3R)-2-(2-fluoro-2-methylpropyl)-2, 3, 4, 9-tetrahydro-3-methyl-1H-pyrido[3, 4-b]indol-1-yl]phenyl]-, (2E)
SMILES
CC1CC2=C(C(N1CC(C)(C)F)C3=C(C=C(C=C3F)C=CC(=O)O)F)NC4=CC=CC=C24
Molecular Formula
C25H25F3N2O2
CAS Number
1639042-08-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD9496 biochemical
A potent, selective estrogen receptor down regulator (SERD) with ER down regulation pIC50 of 9.68; shows pM equipotent binding to both ERalpha and ERbeta isoforms, highly selective binding compared with progesterone (~650-fold), glucocorticoid (~11, 223-fold), and androgen (~36, 375-fold) receptor LBDs; downregulator of ERalpha in vitro and in vivo in ER-positive models of breast cancer and orally available. Breast Cancer Phase 1 Clinical
Product Categories/Family for AZD9496 biochemical
References
1. De Savi C, et al. J Med Chem. 2015 Oct 22; 58 (20):8128-40.
2. Weir HM, et al. Cancer Res. 2016 Jun 1; 76 (11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar; 7 (3):277-287.
2. Weir HM, et al. Cancer Res. 2016 Jun 1; 76 (11):3307-18.
3. Toy W, et al. Cancer Discov. 2017 Mar; 7 (3):277-287.
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Product Notes
The AZD9496 (Catalog #AAA3602477) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD9496, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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