Testing Data
(Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2)
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 Biochemical
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2)
Purity
95% by HPLC
Synonyms
Akt Inhibitor VIII; Isozyme-Selective; Akti-1/2; Akti-1/2 (1; 3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4; 5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2); Akti-1/2 biochemical
Purity/Purification
95% by HPLC
Form/Format
Supplied as a yellow solid.
CAS Number
612847-09-3
Molecular Formula
C34H29N7O
Solubility
DMSO (5mg/ml)
Preparation and Storage
May be stored at 4 degree C. For long-term storage, aliquot and store at 4 degree C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. This product is light sensitive.
Testing Data
(Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2)
Testing Data
(Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2)
Related Product Information for Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 biochemical
A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
Product Categories/Family for Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 biochemical
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Product Notes
The Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Catalog #AAA6074625) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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