Human betaine-homocysteine methyltransferase 2 ELISA Kit | BHMT2 elisa kit

Human Betaine--homocysteine S-methyltransferase 2, BHMT2 ELISA Kit

Cat. Num. AAA9320928

• Reactivity: Human
• Synonyms: betaine-homocysteine methyltransferase 2; Human Betaine--homocysteine S-methyltransferase 2; BHMT2 ELISA Kit; Human Betaine--homocysteine S-methyltransferase 2 (BHMT2) ELISA kit; FLJ20001; ; BHMT2 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Monkey Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 31.2umol/L-1000umol/L
• Sensitivity: 5.0umol/L.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for BHMT2 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of BHBA (hereafter termed "analyte") in undiluted original Monkey body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 295821189
• NCBI GeneID: 23743
• NCBI Accession #: NP_001171476.1
• NCBI GenBank Nucleotide #: NM_001178005.1
• UniProt Accession #: Q9H2M3; Q9NXX7; B7Z516
• Molecular Weight: 40,354 Da
• NCBI Official Full Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform 2
• NCBI Official Synonym Full Names: betaine--homocysteine S-methyltransferase 2
• NCBI Official Symbol: BHMT2
• NCBI Protein Information: S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2
• UniProt Protein Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2
• Protein Family: S-methylmethionine--homocysteine S-methyltransferase
• UniProt Gene Name: BHMT2
• UniProt Synonym Gene Names: SMM-hcy methyltransferase
• UniProt Entry Name: BHMT2_HUMAN

NCBI Description

Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

BHMT2: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.10

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cytosol

Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding

Biological Process: methylation; S-methylmethionine cycle; S-methylmethionine metabolic process; S-adenosylmethionine metabolic process; betaine metabolic process