Beta-hexatoxin-Mg1a Recombinant Protein | Beta-HXTX-Mg1a recombinant protein
Recombinant Macrothele gigas Beta-hexatoxin-Mg1a
NCBI and Uniprot Product Information
Uniprot Description
Function: Insect and vertebrate active toxin. Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes temporary paralysis when injected into lepidopteran larvae at 8.6 nmol/g. A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating. A high injection dose causes extensive lacrimation and death. Ref.2
Subcellular location: Secreted Ref.2.
Tissue specificity: Expressed by the venom gland. Ref.2
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Toxic dose: LD50 is 0.73 pmol/g to mice by intracranial injection. Ref.2
Miscellaneous: The primary structure of the mature toxin is identical to that of beta-hexatoxin-Mr1a (Raventoxin-III) from Macrothele raveni (AC P61232).
Sequence similarities: Belongs to the magi-5 family.
Mass spectrometry: Molecular mass is 3286.8 Da from positions 51 - 79. Determined by MALDI. Ref.2
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Product Notes
The Beta-hexatoxin-Mg1a beta-hxtx-mg1a (Catalog #AAA1165666) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 51-79aa; Cytoplasmic domain. The amino acid sequence is listed below: GCKLTFWKCK NKKECCGWNA CALGICMPR. It is sometimes possible for the material contained within the vial of "Beta-hexatoxin-Mg1a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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