3-Hydroxybutyrate Dehydrogenase Recombinant Protein | BDH2 recombinant protein
Recombinant Human 3-Hydroxybutyrate Dehydrogenase, Type 2
Gene Names
BDH2; DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933
Purity
Greater than 95% as determined by SDS-PAGE.
Synonyms
3-Hydroxybutyrate Dehydrogenase; Recombinant Human 3-Hydroxybutyrate Dehydrogenase; Type 2; BDH2 Human; Type 2 Human Recombinant; 3-hydroxybutyrate dehydrogenase type 2; FLJ13261; PRO20933; SDR15C1; UCPA-OR; UNQ6308; dehydrogenase/reductase (SDR family) member 6; Oxidoreductase UCPA; DHRS6; R-beta-hydroxybutyrate dehydrogenase; EFA6R; EC 1.1.1.30; BDH2 recombinant protein
Host
E Coli
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Form/Format
The BDH2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol.
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL
Sequence Length
245
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.
Related Product Information for BDH2 recombinant protein
Description: BDH2 produced in E Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-245a.a.) and having a molecular mass of 28.8kDa.BDH2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: BDH2 is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH2 protein has a significant part in the peripheral utilization of 3-hydroxybutyrate. BDH2 can convert high levels of circulating 3-hydroxybutyrate into acetoacetate due to cytoplasmic localization in high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters.
Introduction: BDH2 is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH2 protein has a significant part in the peripheral utilization of 3-hydroxybutyrate. BDH2 can convert high levels of circulating 3-hydroxybutyrate into acetoacetate due to cytoplasmic localization in high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters.
Product Categories/Family for BDH2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,626 Da
NCBI Official Full Name
3-hydroxybutyrate dehydrogenase type 2
NCBI Official Synonym Full Names
3-hydroxybutyrate dehydrogenase, type 2
NCBI Official Symbol
BDH2
NCBI Official Synonym Symbols
DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933
NCBI Protein Information
3-hydroxybutyrate dehydrogenase type 2; R-beta-hydroxybutyrate dehydrogenase; dehydrogenase/reductase (SDR family) member 6; dehydrogenase/reductase SDR family member 6; oxidoreductase UCPA; short chain dehydrogenase/reductase family 15C member 1; short chain dehydrogenase/reductase family 15C, member 1
UniProt Protein Name
3-hydroxybutyrate dehydrogenase type 2
Protein Family
UniProt Gene Name
BDH2
UniProt Synonym Gene Names
DHRS6; SDR15C1
UniProt Entry Name
BDH2_HUMAN
Uniprot Description
DHRS6: Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Carbohydrate Metabolism - butanoate; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 1.1.1.30
Chromosomal Location of Human Ortholog: 4q24
Cellular Component: mitochondrion; cytoplasm
Molecular Function: 3-hydroxybutyrate dehydrogenase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; NAD binding
Biological Process: siderophore biosynthetic process; iron ion homeostasis; fatty acid beta-oxidation; epithelial cell differentiation; heme metabolic process
Research Articles on BDH2
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Product Notes
The BDH2 bdh2 (Catalog #AAA145259) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL. It is sometimes possible for the material contained within the vial of "3-Hydroxybutyrate Dehydrogenase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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