B-cell CLL/lymphoma 7A Recombinant Protein | BCL7A recombinant protein

Recombinant Human B-cell CLL/lymphoma 7A

Cat. Num. AAA146396

• Gene Names: BCL7A; BCL7
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: B-cell CLL/lymphoma 7A; Recombinant Human B-cell CLL/lymphoma 7A; BCL7A Human; B-cell CLL/lymphoma 7A Human Recombinant; B-cell CLL/lymphoma 7 protein family member A; BCL7A; BCL7; BCL7A recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: BCL7A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT and 2mM EDTA.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSGRSVR AETRSRAKDD IKRVMAAIEK VRKWEKKWVT VGDTSLRIYK WVPVTEPKVD DKNKNKKKGK DEKCGSEVTT PENSSSPGMM DMHDDNSNQS SIADASPIKQ ENSSNSSPAP EPNSAVPSDG TEAKVDEAQA DGKEHPGAED ASDEQNSQSS MEHSMNSSEK VDRQPSGDSG LAAETSAISQ DLEGVPPSKK MKLEASQQNS EEM
• Sequence Length: 210

Related Product Information for BCL7A recombinant protein

Description: BCL7A Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-210 a.a.) and having a molecular mass of 25.2kDa (Molecular size on SDS-PAGE will appear higher).BCL7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: B-cell CLL/lymphoma 7A (BCL7A) is a member of the BCL7 family. BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. Thru gene translocation, the N-terminal region of the BCL7A gene is disrupted, which is assumed to be connected to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal portion involved in the translocation includes the region which shares a compelling sequence similarity with those of BCL7B and BCL7C. Chromosomal anomalies involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma.

Product Categories/Family for BCL7A recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; B Cell Lymphoma

NCBI and Uniprot Product Information

• NCBI GI #: 67190736
• NCBI GeneID: 605
• NCBI Accession #: NP_001019979.1
• NCBI GenBank Nucleotide #: NM_001024808.2
• UniProt Accession #: Q4VC05; Q13843; Q14CT7; B4DJN6; B7ZB21
• Molecular Weight: 25,029 Da
• NCBI Official Full Name: B-cell CLL/lymphoma 7 protein family member A isoform b
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 7A
• NCBI Official Symbol: BCL7A
• NCBI Official Synonym Symbols: BCL7
• NCBI Protein Information: B-cell CLL/lymphoma 7 protein family member A; B-cell CLL/lymphoma-7
• UniProt Protein Name: B-cell CLL/lymphoma 7 protein family member A
• Protein Family: B-cell CLL/lymphoma 7 protein family
• UniProt Gene Name: BCL7A
• UniProt Entry Name: BCL7A_HUMAN

NCBI Description

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 12q24.13

Biological Process: negative regulation of transcription, DNA-dependent