BCL2L12 recombinant protein

BCL2L12 Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8121711

• Purity: >95% as determined by SDS-PAGE
• Synonyms: BCL2L12; BCL2L12 Protein; Human; Recombinant (GST Tag); Human BCL2L12/BCL2-like 12 Protein (GST Tag); BCL2-like 12 (proline rich); BCL2L12 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Pro147-Lys227

• Species: Human
• Predicted N Terminal: Met
• Tag: N-GST
• Protein Construction: A DNA sequence encoding the human BCL2L12 (Q9HB09-1)(Pro147-Lys227) was fused with the GST tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for BCL2L12 recombinant protein

Background: BCL2-like 12 (BCL2L12) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prognostic and chemotherapy response marker in AML. BCL2L12 mRNA expression may serve as a potential prognostic biomarker in tongue and/or larynx SCC, which principally constitute the great majority of HNSCC cases worldwide. BCL2L12 mRNA expression is a favorable prognostic marker of DFS for BC patients, suggesting its possible application as a novel prognostic indicator of this malignancy.

NCBI and Uniprot Product Information

• NCBI GI #: 100913021
• NCBI GeneID: 83596
• NCBI Accession #: NP_001035758.1
• NCBI GenBank Nucleotide #: NM_001040668.1
• UniProt Accession #: Q9HB09; Q3SY11; Q3SY13; Q96I96; Q9HB08
• Molecular Weight: 36,821 Da
• NCBI Official Full Name: bcl-2-like protein 12 isoform 3
• NCBI Official Synonym Full Names: BCL2-like 12 (proline rich)
• NCBI Official Symbol: BCL2L12
• NCBI Protein Information: bcl-2-like protein 12; bcl2-L-12; Bcl-2 related proline-rich protein; bcl-2-related proline-rich protein
• UniProt Protein Name: Bcl-2-like protein 12
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: BCL2L12
• UniProt Synonym Gene Names: BPR; Bcl2-L-12
• UniProt Entry Name: B2L12_HUMAN

NCBI Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-2L12: belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: membrane; nucleus

Molecular Function: protein binding; p53 binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter