IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Rabbit anti-Human TLR3 Polyclonal Antibody | anti-TLR3 antibody
TLR3 Antibody
Gene Names
TLR3; CD283; IIAE2
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
TLR3, Antibody; TLR3 Antibody; Toll-like receptor 3; CD283; TLR3; anti-TLR3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This TLR3 antibody is generated from rabbits immunized with TLR3 recombinant protein.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Length
904
Applicable Applications for anti-TLR3 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Recombinant Protein
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(Formalin-fixed and paraffin-embedded mouse brain tissue reacted with TLR3 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of TLR3 Antibody in HL-60 cell line lysates (35ug/lane). TLR3 (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of TLR3 Antibody in HL-60 cell line lysates (35ug/lane). TLR3 (arrow) was detected using the purified Pab.)
Related Product Information for anti-TLR3 antibody
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Product Categories/Family for anti-TLR3 antibody
References
Heinz, S., et al., J. Biol. Chem. 278(24):21502-21509 (2003).
Sarkar, S.N., et al., J. Biol. Chem. 278(7):4393-4396 (2003).
Matsumoto, M., et al., Biochem. Biophys. Res. Commun. 293(5):1364-1369 (2002).
Takami, M., et al., J. Immunol. 169(3):1516-1523 (2002).
Kadowaki, N., et al., J. Exp. Med. 194(6):863-869 (2001).
Sarkar, S.N., et al., J. Biol. Chem. 278(7):4393-4396 (2003).
Matsumoto, M., et al., Biochem. Biophys. Res. Commun. 293(5):1364-1369 (2002).
Takami, M., et al., J. Immunol. 169(3):1516-1523 (2002).
Kadowaki, N., et al., J. Exp. Med. 194(6):863-869 (2001).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
103829
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll-like receptor 3
NCBI Official Symbol
TLR3
NCBI Official Synonym Symbols
CD283; IIAE2
NCBI Protein Information
toll-like receptor 3
UniProt Protein Name
Toll-like receptor 3
UniProt Gene Name
TLR3
UniProt Entry Name
TLR3_HUMAN
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Product Notes
The TLR3 tlr3 (Catalog #AAA289750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLR3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TLR3 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the TLR3 tlr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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