Cat Brevican ELISA Kit | BCAN elisa kit
Cat Brevican ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Description
BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Membrane protein, GPI anchor; Secreted
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region
Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding
Biological Process: chondroitin sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; hippocampus development; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process