BAG family molecular chaperone regulator 4 (Bag4) Recombinant Protein | Bag4 recombinant protein
Recombinant Mouse BAG family molecular chaperone regulator 4 (Bag4)
Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
NCBI and Uniprot Product Information
Uniprot Description
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (). Negative regulator of PRKN translocation to damaged mitochondria ().