Aurora-C Blocking Peptide | AURKC blocking peptide

Aurora-C Antibody (Center) Blocking Peptide

• Gene Names: AURKC; AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
• Synonyms: Aurora-C; Aurora-C Antibody (Center) Blocking Peptide; Aurora kinase C; Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; AURKC; AIE2; AIK3; AIRK3; ARK3; STK13; AURKC blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human Aurora-C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 309

• Cellular Location: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis
• Tissue Location: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AURKC blocking peptide

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

NCBI and Uniprot Product Information

• NCBI GI #: 27805738
• NCBI GeneID: 6795
• UniProt Accession #: Q9UQB9; O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5
• Molecular Weight: 33,672 Da
• NCBI Official Full Name: Aurora kinase C
• NCBI Official Synonym Full Names: aurora kinase C
• NCBI Official Symbol: AURKC
• NCBI Official Synonym Symbols: AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C
• NCBI Protein Information: aurora kinase C
• UniProt Protein Name: Aurora kinase C
• Protein Family: Aurora kinase
• UniProt Gene Name: AURKC
• UniProt Synonym Gene Names: AIE2; AIK3; AIRK3; ARK3; STK13; ARK-3; Aurora-related kinase 3
• UniProt Entry Name: AURKC_HUMAN

NCBI Description

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

AurC: a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; AUR family

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis

Disease: Spermatogenic Failure 5