Rat alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) ELISA Kit | ATRX elisa kit
Rat Transcriptional regulator ATRX, ATRX ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ATRX: a global transcriptional regulator. Belongs to the SNF2 family of proteins, many of which modify gene expression via chromatin remodeling activity. Involved in the developmental silencing of imprinted genes in the brain. Contains one PxVxL motif, which is required for interaction with chromoshadow domains. This motif requires additional residues at -7, -6, +4 and +5 relative to the central V which contact the chromoshadow domain. Constitutive mutations in ATRX are associated with brain, facial, and genital abnormalities, and alpha thalassemia. Acquired mutations in ATRX have been observed in preleukemic conditions. Six alternatively spliced human isoforms have been described.
Protein type: DNA repair, damage; Ubiquitin conjugating system; EC 3.6.4.12; Helicase
Cellular Component: nucleoplasm; nuclear chromosome; heterochromatin; PML body; cytoplasm; intracellular; nucleus
Molecular Function: protein binding; DNA binding; histone binding; chromatin binding; DNA translocase activity; helicase activity; ATP binding; methylated histone residue binding
Biological Process: DNA damage response, signal transduction by p53 class mediator; transcription, DNA-dependent; multicellular organism growth; positive regulation of telomere maintenance; DNA repair; Sertoli cell development; replication fork processing; chromatin remodeling; nucleosome assembly; DNA replication-independent nucleosome assembly; post-embryonic forelimb morphogenesis; forebrain development; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
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Product Notes
The Rat ATRX atrx (Catalog #AAA9334326) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334326 ELISA Kit recognizes Rat ATRX. It is sometimes possible for the material contained within the vial of "alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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