Human ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H ELISA Kit | ATP6V1H elisa kit

Human V-type proton ATPase subunit H, ATP6V1H ELISA Kit

Cat. Num. AAA9332969

• Gene Names: ATP6V1H; SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal 50/57kDa; V1 subunit H; Human V-type proton ATPase subunit H; ATP6V1H ELISA Kit; Human V-type proton ATPase subunit H (ATP6V1H) ELISA kit; CGI-11; MSTP042; NBP1; SFD; SFDalpha; SFDbeta; VMA13; V-ATPase H subunit; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; ATP6V1H elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 47717104
• NCBI GeneID: 51606
• NCBI Accession #: NP_057025.2
• NCBI GenBank Nucleotide #: NM_015941.3
• UniProt Accession #: Q9UI12; Q6PK44; Q9H3E3; Q9Y300; B3KMR0
• Molecular Weight: 55,883 Da
• NCBI Official Full Name: V-type proton ATPase subunit H isoform 1
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
• NCBI Official Symbol: ATP6V1H
• NCBI Official Synonym Symbols: SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• NCBI Protein Information: V-type proton ATPase subunit H; V-ATPase subunit H; nef-binding protein 1; protein VMA13 homolog; vacuolar ATPase subunit H; V-ATPase 50/57 kDa subunits; vacuolar proton pump subunit H; vacuolar ATP synthase subunit H; vacuolar proton pump subunit SFD
• UniProt Protein Name: V-type proton ATPase subunit H
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6V1H
• UniProt Synonym Gene Names: CGI-11; V-ATPase subunit H; NBP1
• UniProt Entry Name: VATH_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: lysosomal membrane; plasma membrane; cytosol; vacuolar proton-transporting V-type ATPase, V1 domain

Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity

Biological Process: interaction with host; vacuolar acidification; viral reproduction; regulation of catalytic activity; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus