ATPase Transporting Lysosomal Accessory Protein 2 Recombinant Protein | ATP6AP2 recombinant protein

Recombinant Human ATPase Transporting Lysosomal Accessory Protein 2

Cat. Num. AAA146427

• Gene Names: ATP6AP2; PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9
• Purity: Purity as determined by densitometric image analysis is greater than 90%.
• Synonyms: ATPase Transporting Lysosomal Accessory Protein 2; Recombinant Human ATPase Transporting Lysosomal Accessory Protein 2; ATP6AP2 Human; ATPase Transporting Lysosomal Accessory Protein 2 Human Recombinant; Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit; ATP6AP2; ATP6IP2; CAPER; ELDF10; M8-9; MRXE; XMRE; XPDS; HT028; MRXSH; MSTP009; APT6M8-9; ATP6AP2 recombinant protein

• Host: E Coli
• Purity/Purification: Purity as determined by densitometric image analysis is greater than 90%.
• Form/Format: ATP6AP2 filtered (0.4 um) and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl, pH 7.5.; Filtered White lyophilized (freeze-dried) powder.
• Sequence: MKHHHHHHAS NEFSILKSPG SVVFRNGNWP IPGERIPDVA ALSMGFSVKE DLSWPGLAVG NLFHRPRATV MVMVKGVNKL ALPPGSVISY PLENAVPFSL DSVANSIHSL FSEETPVVLQ LAPSEERVYM VGKANSVFED LSVTLRQLRN RLFQENSVLS SLPLNSLSRN NEVDLLFLSE LQVLHDISSL LSRHKHLAKD HSPDLYSLEL AGLDEIGKRY GEDSEQFRDA SKILVDALQK FADDMYSLYG GNAVVELVTV KSFDTSLIRK TRTILEAKQA KNPASPYNLA YKYNFE.
• Sequence Length: 350

• Solubility: It is recommended to add 200 ul deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ATP6AP2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Related Product Information for ATP6AP2 recombinant protein

Description: ATP6AP2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 296 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 33kDa (calculated).

Introduction: ATPase Transporting Lysosomal Accessory Protein 2 (ATP6AP2) is a protein associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have vital roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. ATP6AP2 is linked with the transmembrane sector of the V-type ATPases, which have a transmembrane proton-conducting sector and an extramembrane catalytic sector. ATP6AP2 serves as a renin and prorenin cellular receptor; it mediates renin-dependent cellular responses by activating ERK1 and ERK2. ATP6AP2 is expressed in the brain, heart, placenta, liver, kidney and pancreas. ATP6AP2 is hardly detectable in the lung and skeletal muscles. ATP6AP2 is also expressed in the vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.

Product Categories/Family for ATP6AP2 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; ATPase

NCBI and Uniprot Product Information

• NCBI GI #: 15011918
• NCBI GeneID: 10159
• NCBI Accession #: NP_005756.2
• NCBI GenBank Nucleotide #: NM_005765.2
• UniProt Accession #: O75787; Q5QTQ7; Q6T7F5; Q8NBP3; Q8NG15; Q96FV6; Q96LB5; Q9H2P8; Q9UG89; B7Z9I3
• Molecular Weight: 35,612 Da
• NCBI Official Full Name: renin receptor
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal accessory protein 2
• NCBI Official Symbol: ATP6AP2
• NCBI Official Synonym Symbols: PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9
• NCBI Protein Information: renin receptor; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal interacting protein 2; ER-localized type I transmembrane adaptor; N14F; V-ATPase M8.9 subunit; embryonic liver differentiation factor 10; prorenin receptor; renin/prorenin receptor; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9
• UniProt Protein Name: Renin receptor
• Protein Family: Renin receptor
• UniProt Gene Name: ATP6AP2
• UniProt Synonym Gene Names: ATP6IP2; CAPER; ELDF10; ATP6M8-9; V-ATPase M8.9 subunit
• UniProt Entry Name: RENR_HUMAN

NCBI Description

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: neuron projection; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; enzyme binding; receptor activity; aspartic-type endopeptidase activity

Biological Process: rostrocaudal neural tube patterning; positive regulation of transforming growth factor-beta1 production; cellular protein metabolic process; regulation of MAPKKK cascade; angiotensin maturation; proteolysis; positive regulation of Wnt receptor signaling pathway; eye pigmentation

Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked