Autophagy-related protein 3 (atg3) Recombinant Protein | atg3 recombinant protein
Recombinant Neosartorya fischeri Autophagy-related protein 3 (atg3)
NCBI and Uniprot Product Information
Uniprot Description
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy ().
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Product Notes
The atg3 atg3 (Catalog #AAA1220557) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-353aa; full length protein. The amino acid sequence is listed below: MNILHSTLST WRDRLAPVSR TSTFRTTGQI TPEEFVLAGD YLVYKFPTWA WADASSPAKR VSYLPPGKQF LVTRGVPCHR RLNENFAGDA GHEDEIVRDM LSGADADDGD GWLRTGGGRD LAEKQAERIK DVRTVDESGN MGEREDDEED IPDMEDDDDD EEAIIREPAG KSTTQPIRTY NLYITYSNFY RTPRLYLSGY LSPSEPLPPH LMMEDIVGDY KDKTVTLEDF PWFDGGLKMA SVHPCRHASV MKTLLDRADA ALKIRRDKLK QAHSAAEANR INSERGLEGL VDETRGLSLN EQQGHAAGGD EWEVLQHDEE DQVAIRVDQY LVVFLKFIAS VTPGIEHDFT MGV. It is sometimes possible for the material contained within the vial of "Autophagy-related protein 3 (atg3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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