Guinea Pig Activating Transcription Factor 6 ELISA Kit | ATF6 elisa kit
Guinea Pig Activating Transcription Factor 6 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM]
Uniprot Description
Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. Ref.9
Subunit structure: Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Tissue specificity: Ubiquitous.
Domain: The basic domain functions as a nuclear localization signal.The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
Post-translational modification: During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases.N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR). Ref.11Phosphorylated in vitro by MAPK14/P38MAPK.
Sequence similarities: Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain.
Research Articles on ATF6
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Product Notes
The Guinea Pig ATF6 atf6 (Catalog #AAA727066) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA727066 ELISA Kit recognizes Guinea Pig ATF6. It is sometimes possible for the material contained within the vial of "Activating Transcription Factor 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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