Alpha-tubulin N-acetyltransferase (Atat1) Recombinant Protein | Atat1 recombinant protein

Recombinant Rat Alpha-tubulin N-acetyltransferase (Atat1)

Gene Names

Atat1; TAT; Mec17; RGD1303066; 3110080J08Rik

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Synonyms

Alpha-tubulin N-acetyltransferase (Atat1); Recombinant Rat Alpha-tubulin N-acetyltransferase (Atat1); Atat1 recombinant protein

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Cat. Num. AAA1342399 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE.

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Sequence Positions

1-421, full length protein

Sequence

MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIVDELGKASAKAQHLPAPITSALRMQSNRHVIYVLKDTSARPAGKGAIIGFLKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSPKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRSPTPSLRATRHSRAAVVDPIPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRETPWGLVAQSCHYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDQVLLQDGSGEEPTHTVAPRAQAPPAQSWMVGGDILNARVIRNLQERRNTRPW

Sequence Length

421

Species

Rat

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #

47059197

NCBI GeneID

361789

NCBI Accession #

NP_997663.1

NCBI GenBank Nucleotide #

NM_212498.1

UniProt Accession #

Q6MG11

Molecular Weight

47,327 Da

NCBI Official Full Name

alpha-tubulin N-acetyltransferase 1

NCBI Official Synonym Full Names

alpha tubulin acetyltransferase 1

NCBI Official Symbol

Atat1

NCBI Official Synonym Symbols

TAT; Mec17; RGD1303066; 3110080J08Rik

NCBI Protein Information

alpha-tubulin N-acetyltransferase 1

UniProt Protein Name

Alpha-tubulin N-acetyltransferase 1

UniProt Gene Name

Atat1

UniProt Synonym Gene Names

Alpha-TAT; Alpha-TAT1; TAT

Uniprot Description

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

Research Articles on Atat1

1. while alphaTAT1 may be important for axonal growth in vitro, neither alphaTAT1 nor HDAC5 had an effect in vivo on the regeneration of sciatic nerves.

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Product Notes

The Atat1 atat1 (Catalog #AAA1342399) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-421, full length protein. The amino acid sequence is listed below: MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIVDEL GKASAKAQHL PAPITSALRM QSNRHVIYVL KDTSARPAGK GAIIGFLKVG YKKLFVLDDR EAHNEVEPLC ILDFYIHESV QRHGHGRELF QYMLQKERVE PHQLAIDRPS PKLLKFLNKH YNLETTVPQV NNFVIFEGFF AHQHRSPTPS LRATRHSRAA VVDPIPAAPA RKLPPKRAEG DIKPYSSSDR EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPDRG PLRPFVPEQE LLRSLRLCPP HPTARLLLAT DPGGSPAQRR RTRETPWGLV AQSCHYSRHG GFNTSFLGTG NQERKQGEQE AEDRSASEDQ VLLQDGSGEE PTHTVAPRAQ APPAQSWMVG GDILNARVIR NLQERRNTRP W. It is sometimes possible for the material contained within the vial of "Alpha-tubulin N-acetyltransferase (Atat1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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